The Côte de Nuits (French pronunciation: ​[kot də nɥi]) is a French wine region located in the northern part of the Côte d'Or, the limestone ridge that is at the heart of the Burgundy wine region. It extends from Dijon to just south of Nuits-Saint-Georges, which gives its name to the district and is the regional center. Though some white and rosé wines are produced in the region, the Côte de Nuits is most famous for reds made from pinot noir. The Côte de Nuits covers fourteen communes. Six produce grand cru wines, in the central district between Gevrey-Chambertin and Nuits-Saint-Georges, with four lesser villages either side. The Grand Crus of the Côte de Nuits are some of the smallest appellations in France, less than a hectare in the case of La Romanée.

Among the northern villages of the Côte de Nuits there are several distinct terroir. Uniquely in Burgundy, Marsannay-la-Côte produces wine of all three colors - red and rosé from Pinot Noir, white from Chardonnay. The 529 acres (214 ha) of the Marsannay appellation extends into Couchey and Chênove. The village of Fixin has its own appellation, but the area of Brochon Côte de Nuits Villages extends into the commune with 55 acres (22 ha) of premier cru vineyards out of 193 acres (78 ha) of Pinot Noir and 3 acres (1.2 ha) of Chardonnay. The village of Gevrey-Chambertin has more Grand Crus than any other village, with nine. Chambertin and its extension Chambertin-Clos de Beze are widely recognized for the quality of their red Burgundy. The other Grand Crus are Mazis-Chambertin, Chapelle-Chambertin, Charmes-Chambertin, Mazoyeres-Chambertin, Griotte-Chambertin, Latricieres-Chambertin and Ruchottes-Chambertin. Morey-Saint-Denis is a small commune with four Grand Crus: Clos de la Roche, Clos St. Denis, Clos des Lambrays and Clos de Tart.

Also among the northern villages, the vineyard soils of Chambolle are particularly chalky, giving the wines a lighter body and finer edge of aromas that complements the usual Côte de Nuits backbone of flavor notes. A little white wine is also made in this area. Wines labelled with Chambolle Premier Cru are usually a blend of some of the 19 individual vineyard Premier Crus, of which only Les Amoureuses and Les Charmes are commonly seen. The Grand Crus are Bonnes Mares (which spills over into Morey-Saint-Denis) and Musigny. The village of Vougeot has just one Grand Cru vineyard - Clos Vougeot - that is massive by Burgundy standards, and produces three times as much wine as the rest of the commune. But the variation in terroir over its 124 acres (50 ha), and the different winemaking styles of its 75+ owners, mean that wines labeled with the vineyard name Clos Vougeot show as much variation as the wines from entire communes elsewhere. The village of Flagey is best known for its Grand Crus of Grands Echézeaux and Echézeaux; its Premier Crus are sold under the label of Vosne-Romanée. Vosne contains some of the most famous names in the wine world, notably Romanée-Conti and La Tâche AOC, two monopoles of the Domaine de la Romanée-Conti. The other Grand Crus are Richebourg, La Romanée (the smallest AOC in France, at 2 acres/0.84 hectares), Romanée-St. Vivant and La Grand Rue.

Amidst the southern villages, Nuits-Saint-Georges the largest town in the region with producers often selling their wine to the north. The local wines are most of 'Villages' quality, and need longer aging in the cellar than most Burgundies of similar quality. Wines from Premeaux-Prissey are sold under the Nuits-Saint-Georges appellation and as Côte de Nuits Villages. Comblanchien gives its name to the seam of limestone in the middle of the Côte d'Or. Its wine is sold as Côte de Nuits Villages. The southernmost village of Corgoloin is also covered by the Côte de Nuits Villages appellation.